Redefining care for people with blood disorders

We are advancing a new generation of disease-modifying treatments for patients living with mutant calreticulin-driven myeloproliferative neoplasms

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Our Focus

Forging a new path in the treatment of blood disorders

Damora Therapeutics is an innovative biotechnology company advancing novel subcutaneous biologics to provide the first targeted, disease-modifying treatments for the approximately 42,000 U.S. patients living with mutant calreticulin (mutCALR)-driven myeloproliferative neoplasms (MPNs).

Essential Thrombocythemia (ET) – a rare chronic blood disorder that causes excess platelet production leading to abnormal clotting or bleeding

Myelofibrosis (MF) – a rare blood cancer where the bone marrow is replaced by scar tissue, preventing the body from producing sufficient healthy blood cells

MutCALR is the disease driver in approximately 25% of ET and 35% of MF cases. There are currently no available treatments for these patients that target the underlying cause of their disease

Our MISSION

Our goal is to fundamentally redefine care for people with blood disorders by bringing forward optimized therapies that dramatically improve patient outcomes

On the left, a mature black woman with grey hair is pictured in a profile view, wearing a blue jacket and holding a yellow mug while looking out over a scenic, misty coastline. The image is framed within a large, red-bordered hexagonal shape.
On the left, a mature black woman with grey hair is pictured in a profile view, wearing a blue jacket and holding a yellow mug while looking out over a scenic, misty coastline. The image is framed within a large, red-bordered hexagonal shape.

SCIENCE & PIPELINE

A new generation of targeted biologics

We target the core drivers of MPNs by developing biologics with best-in-class potential, specifically engineered to treat mutant calreticulin-driven diseases.

The Damora Advantage

Disease-Modifying Therapeutics: Targeting the underlying disease drivers to achieve deep disease modification

Broad Coverage: Designed to be effective across the spectrum of Type 1 and Type 2 CALR mutations in ET and MF

Patient-Centric Convenience: Optimized for convenient subcutaneous administration and infrequent dosing regimens to support a better quality of life

Portfolio Optionality: Multiple therapeutic candidates, leveraging diverse modalities with potential to address the full spectrum of MPN patients

We are advancing multiple programs with best-in-class potential, including our lead asset, DMR-001, an investigational monoclonal antibody therapy targeting mutCALR

A graphic showing a corporate drug development pipeline with four programs progressing through discovery and IND-enabling stages toward clinical milestones. On the right hand side is scientific imagery depicting antibodies.A graphic showing a corporate drug development pipeline with four programs progressing through discovery and IND-enabling stages toward clinical milestones. On the right hand side is scientific imagery depicting antibodies.
scientific imagery depicting antibodies.

ABOUT DMR-001

DMR-001 is an investigational monoclonal antibody therapy targeting mutCALR with best-in-class potential.

  • ​DMR-001 was designed to exclusively bind to mutCALR with exquisite selectivity, potency and extended half-life, with potential to enable highly convenient, infrequent subcutaneous dosing
  • Preclinical studies highlight the potential best-in-class clinical profile of DMR-001, which showed increased binding affinity and inhibition of mutCALR-driven cell proliferation compared to a relevant reference antibody, including an approximately 10-fold increase in potency against Type 2 mutant cells
  • DMR-001 has also been engineered with a clinically validated half-life extension technology with the goal of enabling infrequent subcutaneous administration as a convenient autoinjector. In a preclinical study, DMR-001 achieved an approximately 5-fold increase in half-life compared to a relevant reference antibody

We plan to file a U.S. IND or ex-US CTA for DMR-001 in mid-2026, targeting two clinical proof-of-concept datasets beginning in mid-2027.

Who we are

Deep expertise in oncology and drug development

Jennifer Jarrett photo

Jennifer Jarrett

Chief Executive Officer & Board Director
Jennifer Jarrett is Chief Executive Officer of Damora Therapeutics. She is a seasoned executive with nearly three decades of experience in corporate strategy, finance and investor relations, drug development, and organizational leadership. Most recently, she served as Chief Operating Officer of Arcus Biosciences, a development-stage oncology company. During her tenure, she also served as Chief Financial Officer and a member of the company’s Board of Directors. Prior to Arcus, Ms. Jarrett served as Vice President of Corporate Development and Capital Markets at Uber Technologies, Inc. Previously, she was Chief Financial Officer of Medivation, a commercial oncology company that developed the blockbuster medicine XTANDI® (enzalutamide) for prostate cancer, through the company’s acquisition by Pfizer. Ms. Jarrett spent 20 years in investment banking, including at Citigroup, where she ran the firm’s west coast life sciences investment banking practice, and prior to that at Credit Suisse and Donaldson, Lufkin & Jenrette. Ms. Jarrett received a B.A. in Economics from Dartmouth College and an M.B.A. from Stanford University Graduate School of Business. She serves on the boards of Sagimet Biosciences, Syndax Pharmaceuticals and Zura Bio.
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Sherwin Sattarzadeh

Chief Operating Officer
Sherwin Sattarzadeh is Chief Operating Officer of Damora Therapeutics. He brings over 20 years of industry experience across the many facets and stages of drug development and company lifecycle. Most recently, Mr. Sattarzadeh served as Chief Business Officer at Blueprint Medicines. During his 10 years at Blueprint Medicines, he held positions of increasing responsibility, including Head of Regulatory Affairs, Chief of Staff, and SVP Strategic Operations. He has an extensive background in hematology/oncology and rare disease drug development, having led and contributed to the global approvals of AYVAKIT® (avapritinib), GAVRETO® (pralsetinib), CERDELGA® (eliglustat), and MOZOBIL® (plerixafor). Mr. Sattarzadeh received his M.B.A. from Boston University and holds a B.Sc. in Chemistry from the University of British Columbia.
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Becker Hewes, M.D.

Chief medical Officer
Dr. Becker Hewes is Chief Medical Officer of Damora Therapeutics. Dr. Hewes brings over two decades of experience in drug development in public biotechnology companies. Most recently, he served as Chief Medical Officer at Blueprint Medicines. During his time at Blueprint Medicines, Dr. Hewes led the development of an industry-leading pipeline across mast cell disorders and solid tumors, including the approval of AYVAKIT (avapritinib) for indolent and advanced systemic mastocytosis. Prior to joining Blueprint Medicines, he had an illustrious career in hematology/oncology drug development, having led clinical development and translational medicine efforts for multiple early-stage oncology programs through clinical proof-of-concept, including Kisqali® (ribociclib), as well as leading registration programs for Bosulif® (bosutinib), and Torisel® (temsirolimus). Dr. Hewes received his B.S. from Vanderbilt University and an M.D. from Georgetown University. He completed his residency at New York Hospital/Cornell Medical Center and his fellowship training in Pediatric Oncology at Emory University.
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Garrett Winslow

General Counsel
Garrett Winslow brings more than 15 years of experience working with public companies in the life sciences industry. He previously served as the General Counsel of Galecto, Inc. and Spring Bank Pharmaceuticals, publicly listed clinical-stage biotechnology companies. Prior to that, he was a partner in the Corporate and Securities group at Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. in Boston, Massachusetts, where he advised public and private companies on securities law compliance, corporate governance and transactional matters. Mr. Winslow received his Master’s in Taxation from Boston University Law School, J.D. degree from Suffolk University Law School, and B.A. degree in Business Administration from the University of Washington.
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Lori Firmani

Chief Financial Officer
Lori Firmani has over 25 years of experience serving in financial roles in the biotech sector. She was appointed as Chief Financial Officer in November 2025 and prior to that served as Interim Chief Financial Officer and Vice President, Finance and Corporate Controller. Ms. Firmani served as Chief Financial Officer of Spring Bank Pharmaceuticals, Inc. from April 2020 until its acquisition in November 2020 and prior to that served in financial roles of increasing responsibility from January 2016 to April 2020. Ms. Firmani is a certified public accountant in the Commonwealth of Massachusetts and holds an M.B.A. from Babson College and a B.S. in accounting from the State University of New York at Geneseo.

Join Our Team

United by a single purpose, we are redefining care for those with blood disorders. As we continue to grow, we are seeking new team members who share our commitment to innovative science and improving the lives of patients.

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