Redefining care for people with blood disorders
We are advancing a new generation of disease-modifying treatments for patients living with mutant calreticulin-driven myeloproliferative neoplasms



Our Focus
Forging a new path in the treatment of blood disorders
Damora Therapeutics is an innovative biotechnology company advancing novel subcutaneous biologics to provide the first targeted, disease-modifying treatments for the approximately 42,000 U.S. patients living with mutant calreticulin (mutCALR)-driven myeloproliferative neoplasms (MPNs).
Essential Thrombocythemia (ET) – a rare chronic blood disorder that causes excess platelet production leading to abnormal clotting or bleeding
Myelofibrosis (MF) – a rare blood cancer where the bone marrow is replaced by scar tissue, preventing the body from producing sufficient healthy blood cells
MutCALR is the disease driver in approximately 25% of ET and 35% of MF cases. There are currently no available treatments for these patients that target the underlying cause of their disease
Our MISSION
Our goal is to fundamentally redefine care for people with blood disorders by bringing forward optimized therapies that dramatically improve patient outcomes


SCIENCE & PIPELINE
A new generation of targeted biologics
We target the core drivers of MPNs by developing biologics with best-in-class potential, specifically engineered to treat mutant calreticulin-driven diseases.
The Damora Advantage
Disease-Modifying Therapeutics: Targeting the underlying disease drivers to achieve deep disease modification
Broad Coverage: Designed to be effective across the spectrum of Type 1 and Type 2 CALR mutations in ET and MF
Patient-Centric Convenience: Optimized for convenient subcutaneous administration and infrequent dosing regimens to support a better quality of life
Portfolio Optionality: Multiple therapeutic candidates, leveraging diverse modalities with potential to address the full spectrum of MPN patients
We are advancing multiple programs with best-in-class potential, including our lead asset, DMR-001, an investigational monoclonal antibody therapy targeting mutCALR



ABOUT DMR-001
DMR-001 is an investigational monoclonal antibody therapy targeting mutCALR with best-in-class potential.
- DMR-001 was designed to exclusively bind to mutCALR with exquisite selectivity, potency and extended half-life, with potential to enable highly convenient, infrequent subcutaneous dosing
- Preclinical studies highlight the potential best-in-class clinical profile of DMR-001, which showed increased binding affinity and inhibition of mutCALR-driven cell proliferation compared to a relevant reference antibody, including an approximately 10-fold increase in potency against Type 2 mutant cells
- DMR-001 has also been engineered with a clinically validated half-life extension technology with the goal of enabling infrequent subcutaneous administration as a convenient autoinjector. In a preclinical study, DMR-001 achieved an approximately 5-fold increase in half-life compared to a relevant reference antibody
We plan to file a U.S. IND or ex-US CTA for DMR-001 in mid-2026, targeting two clinical proof-of-concept datasets beginning in mid-2027.

Who we are
Deep expertise in oncology and drug development

Jennifer Jarrett
Chief Executive Officer & Board Director

Sherwin Sattarzadeh
Chief Operating Officer

Becker Hewes, M.D.
Chief medical Officer

Garrett Winslow
General Counsel

Lori Firmani
Chief Financial Officer
Join Our Team
United by a single purpose, we are redefining care for those with blood disorders. As we continue to grow, we are seeking new team members who share our commitment to innovative science and improving the lives of patients.




