Redefining care for people with blood disorders
We are advancing a new generation of disease-modifying treatments for patients living with mutant calreticulin-driven myeloproliferative neoplasms



Our Focus
Forging a new path in the treatment of blood disorders
Damora Therapeutics is an innovative biotechnology company advancing novel subcutaneous biologics to provide the first targeted, disease-modifying treatments for the approximately 42,000 U.S. patients living with mutant calreticulin (mutCALR)-driven myeloproliferative neoplasms (MPNs).
Essential Thrombocythemia (ET) – a rare chronic blood disorder that causes excess platelet production leading to abnormal clotting or bleeding, for which mutCALR is a driver in 25% of cases
Myelofibrosis (MF) – a rare blood cancer where the bone marrow is replaced by scar tissue, preventing the body from producing sufficient healthy blood cells, for which mutCALR is a driver in 35% of cases
Our MISSION
Our goal is to fundamentally redefine care for people with blood disorders by bringing forward optimized therapies that dramatically improve patient outcomes


SCIENCE & PIPELINE
A new generation of targeted biologics
We target the core drivers of MPNs by developing biologics with best-in-class potential, specifically engineered to treat mutant calreticulin-driven diseases.
The Damora Advantage
Disease-Modifying Therapeutics: Targeting the underlying disease drivers to achieve deep disease modification.
Broad Coverage: Designed to be effective across the spectrum of Type 1 and Type 2 CALR mutations in ET and MF.
Patient-Centric Convenience: Optimized for convenient subcutaneous administration and infrequent dosing regimens to support a better quality of life.
Portfolio Optionality: Multiple therapeutic candidates, from Fc-null antibodies to T-cell engagers, with potential to address the range of MPN patient needs.
We are advancing multiple programs with best-in-class potential, including our lead asset, DMR-001, an investigational monoclonal antibody therapy targeting mutCALR. DMR-001 was designed to exclusively bind to mutCALR with exquisite selectivity, potency, and extended half-life, with potential to enable convenient, infrequent subcutaneous dosing.




Who we are
Deep expertise in oncology and drug development

Sherwin Sattarzadeh
Chief Operating Officer

Becker Hewes, M.D.
Chief medical Officer

Garrett Winslow
General Counsel

Lori Firmani
Chief Financial Officer
Join Our Team
United by a single purpose, we are redefining care for those with blood disorders. As we continue to grow, we are seeking new team members who share our commitment to innovative science and improving the lives of patients.




